Topic 3: The generation and response of olfactory fatigue in sensory evaluation
(1) Understanding Olfactory (Previous Content)
(2) The generation of olfactory fatigue

1. Ion channel closure
A classic paper published in the international journal "Science" (Facility of Calmodulin Mediated Odor Adaptation by cAMP Gated Channel Subunits) suggests that during the process of odor perception, calcium ions regulate cyclic nucleotide gated ion channels through calmodulin. So, in short, when we smoke e-cigarettes normally, the ion channels open normally (assuming that 100 chemical signals are converted into 100 electrical signals at this time); When we conduct a large amount of inhalation, excessive calcium ions will negatively regulate the cyclic nucleotide gated ion channels through calmodulin, causing the ion channels to close (at this time, 100 chemical signals can only be converted into very few electrical signals or cannot be converted into electrical signals), leading to the inability of the brain to form odor perception.
2. Receptor saturation

(3) How to deal with olfactory fatigue in sensory evaluation

1. Conduct sensory evaluation in a odorless environment.
Most sensory evaluations of electronic cigarettes are conducted in a mixing room, where the perfumer completes the mixing process and is already experiencing a certain degree of olfactory fatigue. Switching to a odorless room (the selection and layout of the evaluation site will be explained in a separate article), taking a short break before conducting the evaluation will greatly improve the accuracy of sensory evaluation. Many e-cigarette flavorers have noticed this, but it is difficult to make any changes.
2. Breathe fresh air.
After completing a set of evaluations, breathe fresh air and rest for 2-3 minutes before proceeding to the next set of evaluations, which is simple and effective, but very few people can achieve it in practice.
3. Drink water (warm water is best).